Association of the HL-A7 Cross-Reacting Group with a Specific Reaginic Antibody Response in Allergic Man
- 16 February 1973
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4074) , 691-693
- https://doi.org/10.1126/science.179.4074.691
Abstract
A relatively small proportion (17 percent) of individuals highly allergic to ragweed were found to develop marked reaginic (immunoglobulin E-mediated) skin sensitivity to a minor ragweed pollen allergen Ra5 (molecular weight 5200). Sensitivity to Ra5 was significantly associated with the possession of a major histocompatibility antigen of the HL-A7 cross-reacting group. This appears to be the first evidence of a strong association between a specific immune response and a specific group of closely related HL-A antigens in man.Keywords
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