Role of tissue hypermetabolism in stimulation of ventilation by dinitrophenol

Publisher Website
Google Scholar
Abstract
Tissue hypermetabolism may account for increases in ventilation (.ovrhdot.VE) elicited by 2,4-dinitrophenol. Stimulation of .ovrhdot.VE by isomers of dinitrophenol may be unrelated to tissue metabolic rate. To test this latter concept, 3 different isomers of dinitrophenol, i.e., 2,4-dinitrophenol (2,4-DNP), 2,5-dinitrophenol (2,5-DNP) and 2,6-dinitrophenol (2,6-DNP), were compared with respect to stimulation of .ovrhdot.VE and with resepct to stimulation of O2 consumption (.ovrhdot.VO2). In all experiments, 3-4 mg/kg of 1 dinitrophenol isomer was administered to chloralose anesthetized dogs by intra-arterial infusion. 2,4-DNP elicited large increments in both .ovrhdot.VE and .ovrhdot.VO2, 2,6-DNP elicited moderate increments in both .ovrhdot.VE and .ovrhdot.VO2, whereas 2,5-DNP elicited small increments in both .ovrhdot.VE and .ovrhdot.VO2. These observations demonstrate a correlation between ventilatory and metabolic changes effected by isomers of dinitrophenol. These results are consistent with the hypothesis that ventilatory stimulation by congeners of dinitrophenol is related to tissue hypermetabolism.

This publication has 1 reference indexed in Scilit: