Amino-acids and peptides. Part XVIII. Studies relating to the synthesis and conformation of a novel bicyclic peptide system
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 19,p. 2019-2024
- https://doi.org/10.1039/p19760002019
Abstract
The synthesis of a bicyclic system (I) derived by coupling the two fourteen-membered cyclic peptides cyclo-[L-(α-amino)-β-alanylglycyl-D-(α-tosylamino)-β-alanylglycyl](II) and cyclo-[D-β-aspartylglycyl-β-alanylglycyl](III), and related bicyclic compounds, is described. The conformations of the compounds are discussed in the light of evidence from 1H n.m.r. spectroscopy and a crystal structure analysis of one of the monocyclic compounds.This publication has 3 references indexed in Scilit:
- Amino-acids and peptides. Part XVII. Synthesis of cyclo-[(O-t-butyl)-L-seryl-β-alanyl-glycyl-(O-methyl)-L-β-aspartyl], and observations on the rearrangement of β-aspartyl peptide estersJournal of the Chemical Society, Perkin Transactions 1, 1976
- Amino-acids and peptides. Part XVI. Synthesis of cyclo-[L-(α-amino)-β-alanylglycyl-D-(α-amino)-β-alanylglycyl] and related fourteen-membered cyclotetrapeptidesJournal of the Chemical Society, Perkin Transactions 1, 1976
- Three-dimensional Structure of Tosyl-α-chymotrypsinNature, 1967