Effect of generalized spike‐and‐wave discharge on glucose metabolism measured by positron emission tomography

Abstract
Positron emission tomography was used to study the cerebral metabolic rate for glucose (CMRGlc) in 7 adult patients with generalized spike‐and‐wave activity in the electroencephalogram. No consistent changes were seen in the CMRGlc. There was a slight trent toward an increased CMRGlc in 2 patients with primary generalized epilepsy, while in the 5 other patients with minor deviations from this condition or with secondary generalized epilepsy, the CMRGlc was unaffected by spike‐and‐wave activity or was below the normal range. Neither the amount of spike‐and‐wave activity in the EEG nor the presence of clinically evident absence seizures appeared to influence the CMRGlc. Therefore, we conclude that neuronal activity underlying spike‐and‐wave discharge does not seem to require increased glucose utilization.

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