PHARMACOKINETICS OF TETRACYCLINE ENCAPSULATED IN BOVINE CARRIER ERYTHROCYTES
- 1 January 1984
- journal article
- research article
- Vol. 45 (4) , 640-642
Abstract
Tetracycline [an antibacterial agent] was encapsulated in erythrocytes by a dialysis technique. The effect of drug concentration (0.2 mg/ml of erythrocytes) on encapsulation of [14C]sucrose and [3H]tetracycline was reduction of the tetracycline encapsulation, but not [14C]sucrose. Carrier erythrocytes containing tetracycline reinjected in calves were studied for their pharmacokinetic constants. The drug half-life was 6.7 h, with an overall elimination constant of 0.104/h.This publication has 7 references indexed in Scilit:
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