Experimental pathogenicity and mortality in ligated ileal loop studies of the newly reported halophilic lactose-positive Vibrio sp

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Abstract
Laboratory animals were challenged s.c., i.p. and i.v. with the halophilic lactose-positive Vibrio. Inocula i.p. of 108 organisms was rapidly lethal in mice, rats and hamsters. The 50% lethal dose in ICR strain mice was estimated to be 8 .times. 105 live cells, injected i.p. or s.c. Inocula s.c. in mice resulted in severe local infections, characterized by gross edema, and for those animals surviving longer than 48 h, tissue necrosis. Injections i.v., i.p. and s.c. of 108 cells in mice resulted in death within 3-6 h. These animals rapidly developed Vibrio bacteremia after injections. V. parahaemolyticus, studied for comparative purposes, produced no morbidity or mortality when injected s.c. Injections of live lactose-positive Vibrio into ligated ileal loops in rats and rabbits consistently proved to be lethal with a high-density bacteremia resulting.