Solubilization by nitrilotriacetic acid (NTA) of genetically active Cr(VI) and Pb(II) from insoluble metal compounds
- 30 June 1987
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 21 (3) , 387-394
- https://doi.org/10.1080/15287398709531027
Abstract
The frequencies of sister chromatid exchanges (SCE) were significantly increased in cultured Chinese hamster cells by insoluble salts of Cr(VI) (PbCrO4) and Pb(II) (PbSO4). A further significant increase of this effect was produced when diluted suspensions of PbCrO4 (1–4 mg/l) and PbSO4 (10–40 mg/l) were preincubated with nitrilotriacetic acid (NTA) concentrations (0.25–1 mg/l) such as those that are possibly found in highly contaminated environmental situations. NTA enhanced the induction of SCE by PbCrO4 and PbSO4 even in the presence, in the preincubation solution and in the medium used to treat the cells, of Na+ and K+ concentrations largely exceeding (e.g., 102‐106 times) those of the genotoxic metals.This publication has 8 references indexed in Scilit:
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