DNA Vaccination with the Human Immunodeficiency Virus Type 1 SF162ΔV2 Envelope Elicits Immune Responses That Offer Partial Protection from Simian/Human Immunodeficiency Virus Infection to CD8 + T-Cell-Depleted Rhesus Macaques
- 1 February 2001
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (3) , 1547-1550
- https://doi.org/10.1128/jvi.75.3.1547-1550.2001
Abstract
DNA immunization of macaques with the SF162ΔV2 envelope elicited lymphoproliferative responses and potent neutralizing antibodies. The animals were depleted of their CD8 + T lymphocytes and then challenged intravenously with SHIV162P4. Compared to unvaccinated animals, the vaccinated macaques had lower peak viremia levels, rapidly cleared plasma virus, and showed delayed seroconversion.Keywords
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