Isomers of 10-Hydroxynortriptyline in Geriatric Depression
- 1 June 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 10 (2) , 164-167
- https://doi.org/10.1097/00007691-198802000-00008
Abstract
Summary: In geriatric, depressed inpatients treated with nortriptyline (NT), total unconjugated plasma concentrations of the Z isomer of the 10-hydroxylated metabolite (10-OH-NT) were determined simultaneously with concentrations of the E isomer by high-performance liquid chromatography. Z-10-OH-NT concentrations averaged 14% of E-10-OH-NT concentrations.Keywords
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