Detection of Antibody to Hepatitis Bs-Antigen in Patients with Acute and Chronic Hepatitis as Measured by a Modified Procedure of the Radioimmunoassay Ausria I 125®

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Abstract
A simple modification of the radioimmunoassay Ausria I 125® was employed for detecting anti‐HBs using the inhibition of a constant amount of HBs Ag. Anti‐HBs was demonstrated in up to 82% of follow‐up patients recovering from viral hepatitis B and in 79% of hemophilia patients. The antibody was found in 3.4% of healthy blood donors and in 10% of family contacts of patients with acute HBs Ag‐positive viral hepatitis. The frequency of anti‐HBs in 44 patients with HBs Ag‐negative chronic aggressive hepatitis or cryptogenic liver cirrhosis (23%) did not differ significantly as compared with the occurrence of anti‐HBs in 58 patients with chronic rheumatoid arthritis (16%). These findings give further support to the suggestion that the hepatitis B virus does not contribute to the aetiology of HBs Ag‐negative chronic active hepatitis.