EFFECTS OF RADIATION ON HEMATOPOIETIC STROMA

  • 1 January 1976
    • journal article
    • research article
    • Vol. 4  (5) , 310-314
Abstract
The effects of X-irradiation on the [mouse] CFU-S [hemopoietic colony-forming units] and on the hematopoietic stroma (HS-P) were studied and compared. Exposure to 300 rad reduced the CFU-S population to < 1% of normal; by contrast more than 500 rad was required to detectably damage the HS-P. Although exposure to 500 rad did not detectably affect HS-P function, a 2nd exposure to 500 rad at long as 4 wk later did appreciably affect the HS-P. In addition, whereas the CFU-S returned to the pre-irradiation level within 6 wk, the HS-P did not significantly recover. With respect to the initial impact and exposure dose, HS-P is more radioresistant than CFU-S, but recovery from radiation induced damage of HS-P occurs slowly or does not take place.

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