Resistance of Clostridium perfringens to -Lactam Antibiotics Mediated by a Decreased Affinity of a Single Essential Penicillin-binding Protein
- 1 August 1983
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 129 (8) , 2339-2342
- https://doi.org/10.1099/00221287-129-8-2339
Abstract
SUMMARY: Benzylpenicillin-resistant mutants of Clostridium perfringens have been isolated by in vitro selection. The sole mechanism of resistance was a decreased affinity of the highest molecular weight penicillin-binding protein (PBP1) for the antibiotic.This publication has 9 references indexed in Scilit:
- Studies on the Mechanism of Intrinsic Resistance to -Lactam Antibiotics in Group D StreptococciMicrobiology, 1983
- Benzylpenicillin-induced Filament Formation of Clostridium perfringensMicrobiology, 1982
- Mode of action of azthreonamAntimicrobial Agents and Chemotherapy, 1982
- Penicillin-binding proteins in Clostridium perfringensAntimicrobial Agents and Chemotherapy, 1981
- The Role of Penicillin‐Binding Proteins in the Action of Cephalosporins against Escherichia coli and Salmonella typhimuriumEuropean Journal of Biochemistry, 1981
- Physiological properties of penicillin-binding proteins in group A streptococciAntimicrobial Agents and Chemotherapy, 1981
- Penicillin-binding proteins of multiply antibiotic-resistant South African strains of Streptococcus pneumoniaeAntimicrobial Agents and Chemotherapy, 1980
- Altered penicillin-binding components in penicillin-resistant mutants of Bacillus subtilis.Proceedings of the National Academy of Sciences, 1976
- THE ACTION OF PENICILLIN ON CL-WELCHII TYPE-A1950