Creating polyketide diversity through genetic engineering
- 1 January 2003
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. 8 (3) , c1-13
- https://doi.org/10.2741/885
Abstract
Modular polyketide synthases (PKS) are large multifunctional enzymes that synthesize complex polyketides, a therapeutically important class of natural products. The linear order and composition of catalytic sites that comprise the PKS represent a "code" that determines the identity of the polyketide product. By re-programming the PKS through genetic engineering, it is possible to alter the code in a predictable manner to create specific structural modifications of polyketides and to produce new libraries of these natural products.Keywords
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