Pharmacology of Nicotine: Antipyretic, Renal and Adrenocorticotrophic Effects.

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Abstract
Nicotine lowers the temp. of the fevered rat, rabbit and dog. In addition to the previously described antidiuretic effect of nicotine in rat and man, the present expts. indicate high activity in the dog, and independence of this effect from changes in glomerular filtration rate. Nicotine did not lower the renal excretion of phenol red in the dog. Nicotine lowers the concn. of ascorbic acid in the rat adrenal. This effect is completely abolished by total adeno-hypophysectomy.