Hyperalgesia following ischaemia of the ratʼs tail

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Abstract
We have investigated the effects of ischemia on responses to a subsequent noxious stimulus in rats. Tail flick latencies to a noxious thermal stimulus were determined by immersing the tail in water at temperatures ranging from 39 to 49.degree. C. We then produced ischemia by occluding the blood supply to the tail; ischemia was terminated at the first signs of an escape response. Tail flick latencies were recorded immediately after termination of ischemia and at 30 min intervals for another 2 h. Each rat acted as its own control. Tail flick latency decreased after ischaemia; we found a decrease of about 39% immediately after ischaemia, at immersion temperatures above 30.degree. C. The duration of the hyperalgesia increased with increasing water temperatures. Thus noxious ischaemia of the rat tail induced hyperalgesia to subsequent noxious thermal stimuli. The hyperalgesia could have arisen through either central or peripheral mechanisms.