Minimum Alveolar Concentrations (MAC) of Halothane, Enflurane, and Isoflurane in Ferrets

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Abstract
The minimum alveolar concentrations (MAC) of isoflurane, enflurane, and halothane were determined in adult male ferrets during controlled ventilation at normothermia (37°C). Mean (±SD) MAC values for isoflurane (n = 8), enflurane (n = 8), and halothane (n = 8) at 37°C were 1.52 ± 0.10%, 1.99 ± 0.18%, and 1.01 ± 0.10%, respectively. Halothane MAC was reduced by 26% in the presence of 70% N2O. At 29.9 ± 0.2°C, the mean MAC value of halothane (0.85 ± 0.11%) was 16% less than MAC at 37°C. The relative potencies of the halogenated anesthetics are of the same order as those reported for large animals and for humans.