Rapid Determination of Acitretin or Isotretinoin and Their Major Metabolites by High-Performance Liquid Chromatography
- 1 September 1988
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 21 (9) , 1603-1618
- https://doi.org/10.1080/00032718808066515
Abstract
A method is described for the quantitative analysis of acitretin and its isomer metabolite, or of isotretinoin and its principal metabolites, in human plasma. Following a simple extraction, the compounds are determined by reversed-phase high-performance liquid chromatography (HPLC) and detection at 350nm. This method was applied to plasma specimens collected from healthy volunteers and patients receiving single or multiple dose administrations of these compounds.Keywords
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