Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold Water-Immersion Restraint Stress in Rats.

1 January 1995

journal article
Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine

Vol. 176 (2) , 127-130
https://doi.org/10.1620/tjem.176.127

Abstract

SHIAN, W.-M., SASAKI, I., KAMIYAMA, Y., NAITO, H., FUNAYAMA, Y., MATSUNO, S. and MIYAZAWA, T. Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold Water-Immersion Restraint Stress in Rats. Tohoku J. Exp. Med., 1995, 176 (2), 127-130 - To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.

Keywords

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