Comparative Analysis of Sequences at the 5′ End of the Human and Mouse Apolipoprotein B Genes
- 1 June 1991
- journal article
- research article
- Published by Mary Ann Liebert Inc in DNA and Cell Biology
- Vol. 10 (5) , 329-338
- https://doi.org/10.1089/dna.1991.10.329
Abstract
A comparison was made between the DNA sequences in two regions of the mouse and the human apolipoprotein B genes: the 5′-flanking sequence and the region between the first exon and the second intron. Considerable homology was observed, particularly in the immediate 5′ region and in the second intron. Because promoter and enhancer elements have been previously localized to these regions in the human apolipoprotein B gene, it is proposed that regions of conserved base sequence delineate binding regions for regulatory proteins. In some cases, contiguous regions of homology are longer than expected for regions designed as recognition sites for individual nuclear proteins, and may define regions recognizable by a cluster of interacting proteins. Both the human and mouse genes contain repetitive elements and a hypervariable dinucleotide repeat.Keywords
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