MACROPHAGE POPULATIONS IN THE HUMAN-PLACENTA AND AMNIOCHORION
- 1 January 1984
- journal article
- research article
- Vol. 57 (2) , 393-403
Abstract
Fetal and maternal macrophage populations in human utero-placental tissues at different stages of gestation were studied using immunohistological and histochemical techniques. A large population of macrophages was identified within maternal decidualized endometrium in term and 1st trimester tissues, although lymphoid cells also constitute a major component of the bone marrow-derived cells in the decidua of early pregnancy. In contrast, fetal macrophages contributed nearly all of the substantial bone marrow-derived cell population within placental chorionic villous mesenchyme and within the mesenchyme of the term amniochorion. Apart from a small population of stellate intensely HLA-DR positive cells in term placental villous stroma, these extra-embryonic fetal macrophages consistently expressed both the leu-M3 tissue macrophage antigen and lysosomal enzyme activities. The major HLA-DR positive cell population of fetal amniochorion apparently comprises ''classical'' macrophages rather than dendritic type cells. These various macrophage populations may perform vital phagocytic and degradative functions within utero-placental tissues and amniochorion.This publication has 25 references indexed in Scilit:
- Bone-marrow origin of endometrial granulocytes in the early human placental bedJournal of Reproductive Immunology, 1983
- LOCALIZATION OF MAJOR HISTOCOMPATIBILITY COMPLEX (HLA-ABC AND DR) ANTIGENS IN 46 KIDNEYSTransplantation, 1983
- A monoclonal antibody (MMA) thet identifies a differentiation antigen on human myelomonocytic cellsClinical Immunology and Immunopathology, 1982
- Review article: Fcγ receptors in the human placentaPlacenta, 1981
- Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10Cell, 1981
- Monoclonal antibody to a human leukocyte‐specific membrane glycoprotein probably homologous to the leukocyte‐common (L‐C) antigen of the ratEuropean Journal of Immunology, 1980
- Mononuclear phagocytes in the human placentaPlacenta, 1980
- A human thymocyte antigen defined by a hybrid myeloma monoclonal antibodyEuropean Journal of Immunology, 1979
- The cytology of hofbauer cellsThe Anatomical Record, 1970
- The incidence and significance of hofbauer cells in the mature human placentaThe Journal of Pathology and Bacteriology, 1967