MICROWAVE-ASSISTED RAPID HYDROLYSIS AND PREPARATION OF THIOAMIDES BY WILLGERODT-KINDLER REACTION
- 1 January 2001
- journal article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 31 (2) , 317-321
- https://doi.org/10.1081/scc-100000216
Abstract
Aldehydes and aryl alkyl ketones were efficiently transformed to thioamides with the same number of carbon atoms via Willgerodt-Kindler reaction under microwave irradiation in solvent-free conditions. The thioamides obtained were hydrolyzed to corresponding carboxylic acids with microwave dielectric heating in one minute. Both reactions are very fast and the yields are excellent.Keywords
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