Aggregation of amphotericin B in the presence of γ‐cyclodextin

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Abstract
The macrolide antibiotic amphotericin B (AmB) forms an inclusion complex with .gamma.-cyclodextrin (.gamma.-CDx), resulting in a molecularly dispersed state of the drug. The state of aggregation of AmB in different solvents has been studied by absorption (uv-vis) and CD spectroscopy. While in aqueous solutions AmB forms colloid-like multimolecular aggregates, in the presence of .gamma.u-CDx true solutions can be prepared, which show similar spectral properties as AmB dissolved in organic solvents. The AmB-.gamma.-CDx complex can be isolated as an amorphous, stable, water-soluble powder, indicating that .gamma.-CDx is a good carrier for the solubilization of this antibiotic. Using .gamma.-CDx as a carrier, the danger of precipitation of the drug during parenteral or intravenous administration can be largely reduced.