Prostaglandin synthesis inhibition and postprandial intestinal hyperemia

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Abstract
The effect of prostaglandin [PG] synthesis inhibition on the postprandial intestinal hyperemia was examined in the jejunum of anesthetized dogs. Both i.v. and i.v. and intra-arterial [i.a.] infusion of the cyclooxygenase inhibitors indomethacin and mefenamic acid reduced resting jejunal blood flow and markedly enhanced the food-induced jejunal hyperemia. The jejunal vascular response to food did not change after either i.v. or i.a. infusion of the carrier solutions or i.a. infusion of angiotensin II. The enhancement of the jejunal hyperemia was associated with an increase in the food-induced increase in jejunal O2 consumption. Infusion of the cyclooxygenase inhibitors increased the mean amplitude of the monophasic intestinal contractions; this did not appear to play a role in the enhancement of the food-induced hyperemia. Inhibition of PG synthesis had a marked effect on the postprandial intestinal hyperemia and this may be due to its enhancement of the jejunal metabolic response to food. The PG involved and their mechanism of action are unknown.

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