ROLE OF PERIPHERAL POOLING IN PORCINE ESCHERICHIA-COLI SEPSIS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 12  (2) , 115-123
Abstract
In anesthetized pigs the effects of E. coli (2 .times. 108/kg) on hemodynamics and red cell distribution were studied. After injection of 99mTc red cells (15 mCi), regional radioactivity was followed during 3 h. Gated bloodpool studies were performed to measure end-diastolic volumes (EDV). E. coli was infused in 14 pigs, while 7 animals served as controls. E. coli resulted in an early increase in pulmonary arterial pressure. Systemic arterial pressure decreased gradually, while cardiac output did not change significantly. The gated studies revealed that especially left ventricular end-diastolic volume (LVEDV) declined, to 50% of the basal value. Regional radioactivity did not change over lungs, liver and abdomen. Splenic activity declined markedly. Over the hindlimb a significant increase (29 .+-. 8%) was observed. Evidently, E. coli infusion in pigs induces a hemodynamic pattern similar to human sepsis. The decrease in LVEDV is probably related to peripheral pooling and a change in right ventricle (RV) performance.

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