NINHYDRIN, CRYSTALLINE PAPAIN AND FIBRIN CLOT

Abstract
Dark-field microscopy reveals the similar appearance of fibrin clots formed in prothrombin-free fibrinogen by tryptase-free thrombin; and crystalline papain. The latter clots, unlike the former, undergo subsequent fibrinolysis. The dark-field appearances of the "pseudo-clots" formed by the action of ninhydrin on fibrinogen solns., are quite different. An analysis of the behavior of ninhydrin in experimentally isolated clotting systems shows it to be without significant effect upon the fundamental coagulation mechanisms.

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