Effect of Chlorothiazide on the Edema of Cirrhosis, Nephrosis, Congestive Heart Failure and Chronic Renal Insufficiency
- 21 November 1957
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 257 (21) , 1016-1022
- https://doi.org/10.1056/nejm195711212572103
Abstract
CHLOROTHIAZIDE (6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide), a nonmercurial diuretic agent, has aroused considerable interest since preclinical studies1 demonstrated a potent chloruretic as well as natriuretic effect.Chlorothiazide is only a moderate carbonic anhydrase inhibitor in vitro, having about ten times the activity of sulfanilamide and one twenty-fifth the potency of acetazolamide.2 The drug appears to be distributed in extracellular fluid. It is concentrated in liver but not in erythrocytes. It is excreted substantially in urine and also in bile. It does not appear in cerebrospinal fluid, aqueous humor or fat. The drug does not possess analgesic, anticonvulsant or antihistaminic activity, nor does it act . . .Keywords
This publication has 7 references indexed in Scilit:
- Failure of renal response to acetazolamide and to meralluride in a dog with chronic nephritisThe American Journal of Medicine, 1957
- REACTIONS TO THE ORGANOMERCURIAL COMPOUNDSAnnals of the New York Academy of Sciences, 1957
- MedicineThe Lancet Healthy Longevity, 1949
- ON THE COLORIMETRIC DETERMINATION OF CREATININE BY THE JAFFE REACTIONJournal of Biological Chemistry, 1945
- AN ACCURATE METHOD FOR THE DETERMINATION OF BLOOD UREA NITROGEN BY DIRECT NESSLERIZATIONPublished by Elsevier ,1942
- DANGER OF INTRAVENOUS MERCURIAL INJECTIONS IN NEPHROSISPublished by American Medical Association (AMA) ,1941
- A SIMPLE AND ACCURATE METHOD FOR THE DETERMINATION OF CHLORIDE IN BIOLOGICAL FLUIDSJournal of Biological Chemistry, 1941