Carbonyl Iron in Humoral Antibody Responses

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Abstract
Summary Carbonyl iron (metallic iron of small spherical particles) had strong adjuvant effect for antibodies to sheep red blood cells in rats. It had a lesser effect with bovine serum albumin and ferritin, and was distinctly inferior to Freund's adjuvant for those antigens. Both local and systemic factors contributed to the adjuvancy of carbonyl iron. The adjuvancy of a series of particulate agents toward ferritin was proportional to the degree of adsorption of this antigen on the particles.

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