Cannabis. Part 25. Synthesis of cannabispirenone-B and its 5,7-difluoro-analogue
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2403-2405
- https://doi.org/10.1039/p19820002403
Abstract
The naturally occurring cannabispirenone-B (1a) was synthesized by spiroannelation of the piperidine enamine of 5,7-dimethoxyindan-1-carbaldehyde to O-methylcannabispirenone (1b), followed by selective demethylation with lithium iodide in 2,4,6-collidine. Its 5,7-difluoro-analogue (10) was synthesized by spiroannelation of 5,7-difluoroindan-1-carbaldehyde obtained by homologation of 5,7-difluoroindan-1-one, which was synthesized from 1-bromo-3,5-difluorobenzene in three steps.This publication has 0 references indexed in Scilit: