IGD MYELOMA WITH MYELOFIBROSIS AND AMYLOIDOSIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 101  (1) , 10-13
Abstract
Two patients with IgD [immunoglobulin D] myeloma protein and .lambda. L chains are described. They had marked Bence Jones proteinuria, were treated wtih melphalan, prednisone and allopurinol and died in less than 1 yr. At autopsy there was extensive myelofibrosis associated with neoplastic infiltrates of plasma cells in both cases. On electrophoresis the serum and urine Bence Jones protein of 1 patient migrated in the .alpha.2 region, and the blood vessels of the other patient contained many nodular deposits of amyloid. Because these findings are rare in multiple myeloma, they may be unique to IgD myeloma.

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