EFFECT OF THYROIDECTOMY OF YOUNG MALE GOATS UPON CERTAIN AP HORMONES12

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Abstract
A group of 8 [male] kids was thyroidectomized between the ages of 5 and 24 days, then killed at about 4 mos. of age after growth stasis had appeared. Pituitaries were assayed for the lactogenic, thyrotrophic, gonadotrophic and sugar elevating factor in comparison with groups of normals of the same wt. (but younger) and of the same age (but of normal wt.). Both the lactogenic and thyrotrophic hormones were present in the cretinous pituitaries in concs. comparable to the normals of similar age; thus they do not appear to be the cause of the growth stasis. This observation is believed to be significant in the light of Riddle''s claim that these 2 factors have a synergistic influence upon somatic growth. The gonadotrophic hormone was present in low conc. and the testes showed lack of stimulation, averaging lighter than the youngest group of normal controls. Of the hormones of the pituitary which are concerned with metabolism, only the sugar elevating factor was studied. It was extremely low in conc. in the cretinous pituitaries. However, histological abnormality of the pancreas and the low liver wt. indicated that thyroidectomy is followed by serious derangement of the glands and organs concerned with carbohydrate metabolism and suggested the possibility that this condition coupled with the low metabolic rate of the somatic cells plays an important role in the growth stasis observed.

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