Release of Interleukin-6 from Anterior Pituitary Cell Aggregates: Developmental Pattern and Modulation by Glucocorticoids and Forskolin
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 53 (1) , 29-34
- https://doi.org/10.1159/000125693
Abstract
The release of the immunologically active cytokine interleukin-6 (IL-6) by cultured anterior pituitary cell aggregates was found to increase with the age of the donor rats. The glucocorticoid hormone dexamethasone (DEX) dose-dependently inhibited the release of IL-6, the IC50 being 2.43 ± 0.93 nM. The sex steroids dihydrotestosterone and estradiol were without detectable effect. The adenylate cyclase activator forskolin increased IL-6 release in aggregate cultures in the presence of DEX. It is concluded that IL-6 release by anterior pituitary cells is subject to developmental changes and under regulatory control of biologically active substances.Keywords
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