Simple Chiral Liquid Chromatographic Enantioseparation of Some Racemic Antiepileptic Drugs
- 1 September 1993
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 16 (13) , 2741-2749
- https://doi.org/10.1080/10826079308019609
Abstract
Cellulose tris (4-methylbenzoate) known as Chiralcel OJ chiral stationary phase (CSP) has been successfully used for the enantioseparation of three clinically used antiepileptic drugs namely, mephobarbital, mephenytoin and benzonal. The chemical structure-chiral recognition mechanisms related to the enantiomeric elution order of these dns are discussed.Keywords
This publication has 27 references indexed in Scilit:
- Determination of mephenytoin stereoselective oxidative metabolism in urine by chiral liquid chromatography employing β-cyclodextrin as a mobile phase additiveJournal of Chromatography B: Biomedical Sciences and Applications, 1992
- Enantiomer separation of chiral barbiturates and of α-lipoic acid by capillary gas chromatography with modified cyclodextrins as chiral stationary phasesJournal of Chromatography A, 1990
- The influence of age and gender on the stereoselective metabolism and pharmacokinetics of mephobarbital in humansClinical Pharmacology & Therapeutics, 1990
- Capillary gas chromatographic separation of enantiomers with stable dipentyl-α, β- and γ-cyclodextrin-derivatized stationary phasesAnalytica Chimica Acta, 1990
- Enantioselective binding of mephobarbital to plasma proteinsChirality, 1990
- Some structural requirements for resolution of hydantoin enantiomers with a β-cyclodextrin liquid chromatography columnJournal of Chromatography A, 1987
- Separation of Drug Stereoisomers by the Formation of β-Cyclodextrin Inclusion ComplexesScience, 1986
- Resolution of enantiomers by HPLC on cellulose derivativesChromatographia, 1984
- Chromatographische Racemattrennungen, 12. Mitt. Trennung chiralerN-Methylbarbiturate und Phenylcyanessigester an CellulosetriacetatArchiv der Pharmazie, 1984
- Chromatographische Racemattrennungen, XI. Vergleich von optisch aktiven Polyamiden mit CellulosetriacetatEuropean Journal of Inorganic Chemistry, 1983