Effects of gonadal steroids on the opioid regulation of LH and prolactin release in ovariectomized pony mares
- 1 November 1995
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 147 (2) , 195-202
- https://doi.org/10.1677/joe.0.1470195
Abstract
The aim of the present study was to investigate the role of ovarian steroids in the opioid regulation of LH and prolactin release in mares. Effects of the opioid antagonist naloxone on LH and prolactin secretion were determined in ovariectomized pony mares. The animals were pretreated with either progesterone (500 μg kg−1) or oestradiol benzoate (10 μg kg−1) for 8 days and subsequently with a combination of progesterone and oestradiol for an additional 8 days. Naloxone administration (0·5 mg kg−1 i.v.) resulted in a significant release of LH as well as prolactin in mares after pretreatment with either oestradiol benzoate or progesterone plus oestradiol benzoate (PJournal of Endocrinology (1995) 147, 195–202Keywords
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