Granuloma Annulare and Human Immunodeficiency Virus Infection
Open Access
- 1 November 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 135 (11) , 1341-1346
- https://doi.org/10.1001/archderm.135.11.1341
Abstract
CUTANEOUS manifestations of human immunodeficiency virus (HIV) infection are diverse and include neoplasms, infections, and inflammatory conditions.1,2 In 1985, Penneys and Hicks3reported the cases of 2 patients with the acquired immunodeficiency syndrome (AIDS) who presented with a disseminated papular eruption resembling granuloma annulare (GA). Since then, 21 other cases of GA in HIV-infected patients have been reported4-17in the English-language literature. A report17raised questions regarding the relation of HIV-associated GA and Epstein-Barr virus (EBV) infection. Generalized GA has been reported13to be more prevalent than localized GA in HIV-infected patients. Because 34 patients with concurrent GA and HIV disease have been seen at our institution in 11 years, we undertook this study to characterize HIV-associated GA by clinical, microscopic, and molecular methods and to investigate the role of EBV infection in the pathogenesis of GA.Keywords
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