Pathological Prion Protein in the Tongues of Sheep Infected with Naturally Occurring Scrapie
Open Access
- 1 May 2005
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 79 (9) , 5847-5849
- https://doi.org/10.1128/jvi.79.9.5847-5849.2005
Abstract
Tongue involvement by prion spreading was shown to be a common outcome after oral or intracranial experimental challenge with scrapie and transmissible mink encephalopathy sources in rodent models. It is also known that bovine spongiform encephalopathy, which is pathogenic for humans, is experimentally transmissible to sheep and can lead to a disease indistinguishable from scrapie. A recent European Food Safety Authority opinion recommended research into PrP sc accumulation in the tongues of ruminants. We report on the detection of PrP sc in the tongues of seven scrapie-infected sheep by immunohistochemistry and Western blotting.Keywords
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