In-vitro activity of fleroxacin against urinary tract and genital tract pathogens

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Abstract
The activity of fleroxacin was compared to those of nalidixic acid, ampicillin, trimethoprim-sulphamethoxazole, tetracycline and penicillin against a total of 452 strains isolated from urinary tract and genital tract infections. These included strains resistant to gentamicin, methicillin-resistant Staphylococcus aureus and ß-lactamase producing strains. MICs were determined by a standard agar dilution procedure using Mueller—Hinton agar. Fleroxacin inhibited 90% of Escherichia coli, Klebsiella pneumoniae, Proteus spp., and Enterobacter spp. at ⩽ 1 mg/1. All the gentamicin-resistant Enterobacteriaceae strains were highly susceptible to fleroxacin (MIC90 ⩽ 0·5 mg/1). Against Pseudomonas, fleroxacin was the most active agent tested (MIC90 2 mg/1). All nalidixic acid-resistant strains were susceptible to fleroxacin (MIC90 ⩽1 mg/1). The activity of fleroxacin was similar against methicillin-resistant and methicillin-susceptible strains of Staph, aureus (MIC90 0·5 mg/1). Against Neisseria gonorrhoeae, fleroxacin (MIC90 0·12 mg/1) was as active as penicillin and tetracycline. However against N. gonorrhoeae strains producing ß-lactamase, fleroxacin (MIC90 ⩽¶5 mg/1) was at least twice as active as tetracycline. Fleroxacin is a potent quinolone with in-vitro activity against a variety of resistant bacterial species.

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