Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report
- 1 December 2001
- journal article
- case report
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 28 (12) , 1157-1160
- https://doi.org/10.1038/sj.bmt.1703308
Abstract
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect. Bone Marrow Transplantation (2001) 28, 1157–1160.Keywords
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