Practical Synthesis of Some Versatile Chiral Building Blocks from (D)-Mannitol
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (05) , 403-406
- https://doi.org/10.1055/s-1986-31653
Abstract
The three chiral building blocks ethyl 4,5-O-isopropylidene-(E)-(S)-4, 5-dihydroxy-2-pentenoate [1,3-dioxolane derivative (E)-(S)-1a], (S)-5-hydroxy-4-pentanolide [(S)-2a], and (S)-5-hydroxy-2-penten-4-olide [(S)-3a] are conveniently prepared from 1,2;5,6-di-O-isopropylidene-D-mannitol (4) via a glycol cleavage and Horner-Emmons reaction sequence.Keywords
This publication has 0 references indexed in Scilit: