The Influence of Gastrin-Related Peptides on HCl Secretion in Man and in Cats with Gastric Fistulas and Heidenhain Pouches

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Abstract
The effectiveness of gastrin-like peptides and histamine on HCl secretion was compared in humans and in cats with gastric fistulas and Heidenhain pouches. The C-terminal penta-peptide and tetrapeptide analogues were used in randomized study with histamine dihydrochloride. The maximal responses of the innervated stomach to gastrin-related penta- and tetrapeptides were distinctly higher than to histamine in humans and similar or slightly higher in animals. Neither peptide when administered in a large, rapid, intravenous dose evoked an inhibitory effect from the vagally innervated stomach (gastric fistula) stimulated by repeated doses of subcutaneously injected histamine. Vagotomy of the fundic gland area (Heidenhain pouch) reduced the sensitivity of the parietal cells to gastrin related peptides in a higher degree than to histamine.