Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 4. Synthesis of the C37-C54 SubunitviaStereoselective Construction of Three Consecutive J, K, and L Rings
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (01) , 46-48
- https://doi.org/10.1055/s-1994-22733
Abstract
A stereoselective synthesis of the C37-C54 subunit of halichondrin B via coupling between the C38-C43 fragment starting from D-tartaric acid and the C44-C54 fragment strating from L-tartaric acid is reported. Construction of three consecutive J, K, and L rings and introduction of asymmetric centers at C51 and C53 were important steps.Keywords
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