Why Is Evidence on Job Strain and Coronary Heart Disease Mixed? An Illustration of Measurement Challenges in the Whitehall II Study

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Abstract
Objective: Evidence regarding the status of job strain as a risk factor for coronary heart disease (CHD) is mixed, including both results supporting the risk status and null findings. However, previous studies have typically assessed job strain at one point in time only. We examined whether the failure of such measurement to reflect long-term job strain could contribute to false null findings.