NSAIDs,Helicobacter pylori,and Pandora's Box

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Abstract
Widespread use of nonsteroidal antiinflammatory drugs (NSAIDs) among the elderly has resulted in a large population of persons at risk for ulcer complications. Selective cyclooxygenase-2 (COX-2) inhibitors were introduced with the hope that they would not cause gastrointestinal complications. However, it is not clear that this has been the case, and now that the dust has settled somewhat, it is possible to take a dispassionate look at the problem.1,2 In this issue of the Journal, Chan et al.3 report a randomized comparison of celecoxib and diclofenac plus omeprazole among patients in Hong Kong who had previously had bleeding from . . .