Defective DNA Repair in a Large Family Having a High Occurrence of Cancer
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 45 (6) , 444-447
- https://doi.org/10.1159/000226663
Abstract
DNA repair synthesis induced by UV light was investigated in unstimulated lymphocytes of 18 healthy members of a large family. Three generations were included: the mother (82 years), her 11 surviving adult children (34-52 years) and 6 of her grandchildren (20-23 years). In the first generation on the paternal side the father and 4 of his 7 siblings had suffered from cancer, in the second generation 1 son and 1 daughter. [3H]-Thymidine incorporation was taken as the parameter for the DNA repair synthesis. DNA repair synthesis was reduced in 14 out of 18 family members: 1 in the first generation, 7 in the second generation, and all 6 in the third generation. In comparison only 14 out of 92 aged-matched controls showed a defective DNA repair. Results provide further evidence that first-degree relatives of cancer patients have an increased incidence of defective DNA repair.This publication has 4 references indexed in Scilit:
- Reduced DNA repair synthesis in healthy women having first degree relatives with breast cancerEuropean Journal of Cancer and Clinical Oncology, 1987
- Impaired DNA-repair synthesis in lymphocytes of breast cancer patientsEuropean Journal of Cancer and Clinical Oncology, 1986
- Inhibition of DNA repair in ultraviolet-irradiated human cells by hydroxyureaBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979
- High blood pressure related to carcinogen-induced unscheduled DNA synthesis, DNA carcinogen binding, and chromosomal aberrations in human lymphocytes.Proceedings of the National Academy of Sciences, 1976