EFFECT OF ADRENALECTOMY AND OF HYDROCORTISONE ON THE TOTAL AMOUNT OF HAEMOGLOBIN AND BLOOD VOLUME IN MALE RATS

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Abstract
Experimental data indicate that adrenal cortical function is not necessary in the rat for normal hematopoiesis. Following adrenalectomy the average vascular tone is decreased and the blood volume correspondingly increased. If the hematopoiesis is not increased parallel to this, the hemoglobin concentration falls. A dose of about 1.5 mg of hydrocortisone per day re-establishes the vascular tone. The administration of higher doses of hydrocortisone to adrenalectomized or normal rats produces a significant decrease in body weight and consequently, in relation to body weight, an increase of the total amount of hemoglobin and blood volume. This effect can not be interpreted as a specific stimulation of hematopoiesis.

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