Platelet-reactive sites in collagen. Collagens I and III possess different aggregatory sites
- 1 December 1987
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 248 (2) , 483-487
- https://doi.org/10.1042/bj2480483
Abstract
Collagen type III possesses a highly reactive platelet-aggregatory site at a locus which in type I is essentially inactive whilst the latter collagen possesses reactive sites absent in type III. It is proposed that platelet aggregation by collagen involves the sequence GK[or R]PG(EY)GPK[or R]G(EY) or, less favourably, GPK[or R]G(EY)G(XY)GK[or R]PG(EY), one basic residue acting in combination with the second in an adjacent .alpha.-chain.This publication has 23 references indexed in Scilit:
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