Alterations in Tissue Plasma Volume With Nembutal Anesthesia

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Abstract
Effect of Nembutal administration on tissue plasma volume was determined in mice. Following the administration of Nembutal the circulating plasma volume increases from 1.1 ml to 1.3 ml. The plasma volume of the liver, kidney, spleen, lung and intestine exhibit an increase of about 35, 80, 85, 15 and 40%, respectively. The plasma volume of the skin displays a reduction of about 15%, while that of muscle reveals no significant change. These alterations in tissue plasma volume were not the result of changes in the capillary permeability to or the rate of metabolism of the injected radioiodoalbumin tracer.