Inositol phospholipid hydrolysis in human brain; adenosine inhibition of the response to histamine

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Abstract
1 Inositol phospholipid hydrolysis was examined in human cerebral cortex slices by a [3H]-inositol prelabelling assay. 2 Enhancement of [3H]-inositol phosphates accumulation was observed in the presence of carbachol, noradrenaline, histamine, 5-hydroxytryptamine (5-HT) and depolarizing concentrations of KCl. 3 Despite having no effect alone, adenosine (and its analogue 2-chloroadenosine) selectively inhibited the direct response to histamine. 4 The inhibition due to adenosine was antagonized by theophylline, but not by 8-cyclopropyltheophylline.