DETERMINATION OF SIGNIFICANT RELATIVE RISKS AND OPTIMAL SAMPLING PROCEDURES IN PROSPECTIVE AND RETROSPECTIVE COMPARATIVE STUDIES OF VARIOUS SIZES

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Abstract
Methods are given for determining the relative risks which it is possible to demonstrate as statistically significant with given probability in prospective and retrospective studies of a particular size. Also considered is the ratio of the sample sizes in the two groups being compared which will provide the most precise estimate of relative risk for a given total sample size.