STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. VIII. THE PHYSIOLOGICAL DISPOSITION OF PAMAQUINE 123
Open Access
- 1 May 1948
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 27 (3 Pt 2) , 114-120
- https://doi.org/10.1172/jci101948
Abstract
Evidence, for the most part indirect, indicates rapid and complete absorption of pamaquine from the gastro-intestinal tract. By direct analysis, moderate degrees of localization in liver, lung and brain were demonstrated in the dog. Presumably, substantially the same situation obtains in man. Urinary excretion of pamaquine is very small (1%) in the dosage range studied. Disposal of the drug is almost entirely by metabolic alteration. This proceeds at a rapid rate, since 8-12 hrs. suffice for the disappearance of 60-mg. doses. The relationship between oral and intramusc. dosage and resulting plasma pamaquine concn. is presented. Quinacrine inhibits the metabolic alteration and possibly the localization of pamaquine.Keywords
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