Enhanced binding of [3H] (-) adrenaline to platelets of depressed patients with melancholia: Effect of long-term clomipramine treatment

Publisher Website
Google Scholar
Abstract
— The specific binding of the full agonist [3H] (-) adrenaline to platelet membranes was measured in 14 drug-free depressed patients with melancholia. There was an increased number of binding sites (Bmax) with the same apparent affinity (KD) for the radioligand, indicating that platelet α2-adrenoceptor density in the high affinity state was increased in depressed patients. Long-term administration of clomipramine was associated with decreases in platelet α2-adrenoceptor densities which correlated with the duration of treatment. The results support the hypothesis that in endogenous depression there is a dysfunction of the α2-adrenoceptor and that antidepressant treatment might involve a time-dependent desensitization process of this receptor.